abstract：:Diabetic peripheral neuropathy (DPN) is a microvascular complication of diabetes mellitus. The aim of this meta-analysis was to evaluate the effects of methylenetetrahydrofolate reductase (MTHFR) 677 C>T and ACE I/D polymorphisms in the development of DPN. We systematically reviewed published studies on MTHFR 677 C>T ...

journal_title：Molecular neurobiology

authors： Wu S,Han Y,Hu Q,Zhang X,Cui G,Li Z,Guan Y

更新日期：2017-05-01 00:00:00

abstract：:Autophagy is an intracellular catabolic mechanism for the degradation of cytoplasmic constituents in the autophagosomal-lysosomal pathway. This mechanism plays an important role in homeostasis and it is defective in certain diseases. Preceding studies have revealed that autophagy is developing as an important moderato...

journal_title：Molecular neurobiology

authors： Cordaro M,Paterniti I,Siracusa R,Impellizzeri D,Esposito E,Cuzzocrea S

更新日期：2017-05-01 00:00:00

abstract：:Astroglial scaring and limited neurogenesis are two problematic issues in recovery of spinal cord injury (SCI). In the meantime, it seems that mechanical manipulations of scaffold to inhibit astroglial scarring and improve neurogenesis is worthy of value. In the present investigation, the effect of nanofiber (gel) con...

journal_title：Molecular neurobiology

authors： Tavakol S,Mousavi SMM,Tavakol B,Hoveizi E,Ai J,Sorkhabadi SMR

更新日期：2017-05-01 00:00:00

abstract：:Astrocyte-mediated inflammation is associated with degenerative pathologies such as Alzheimer's and Parkinson's diseases and multiple sclerosis. The acute inflammation and morphological and metabolic changes that astrocytes develop after the insult are known as reactive astroglia or astrogliosis that is an important r...

journal_title：Molecular neurobiology

authors： Iglesias J,Morales L,Barreto GE

更新日期：2017-05-01 00:00:00

abstract：:CX3CL1 (fractalkine) is the only member of the CX3C (delta) subfamily of chemokines which is unique and combines the properties of both chemoattractant and adhesion molecules. The two-form ligand can exist either in a soluble form, like all other chemokines, and as a membrane-anchored molecule. CX3CL1 discloses its bi...

journal_title：Molecular neurobiology

authors： Poniatowski ŁA,Wojdasiewicz P,Krawczyk M,Szukiewicz D,Gasik R,Kubaszewski Ł,Kurkowska-Jastrzębska I

更新日期：2017-04-01 00:00:00

abstract：:Metabolic stress induced by high-fat (HF) diet leads to cognitive dysfunction and aging, but the physiological mechanisms are not fully understood. Senescence-accelerated prone mouse (SAMP8) models were conducted under metabolic stress conditions by feeding HF for 15 weeks, and the preventive effect of resveratrol was...

journal_title：Molecular neurobiology

authors： Palomera-Avalos V,Griñán-Ferré C,Puigoriol-Ilamola D,Camins A,Sanfeliu C,Canudas AM,Pallàs M

更新日期：2017-04-01 00:00:00

abstract：:The infections of prion agents may cause progressive and fatal neurodegenerative diseases in humans and a serial of animal species. Previous studies have proposed that the levels of nitric oxide (NO) and nitric oxide synthase (NOS) in the brains of some neurodegeneration diseases changed, while S-nitrosylation (SNO) o...

journal_title：Molecular neurobiology

authors： Chen LN,Sun J,Yang XD,Xiao K,Lv Y,Zhang BY,Zhou W,Chen C,Gao C,Shi Q,Dong XP

更新日期：2017-04-01 00:00:00

abstract：:For the epigenetic characterization of neuromyelitis optica (NMO), we determined whether messenger RNAs (mRNAs) and long noncoding RNAs (lncRNAs) are expressed differentially in subjects with and without NMO. lncRNA and mRNA expression profiles of NMO patients and healthy controls were generated by using microarray an...

journal_title：Molecular neurobiology

authors： Xu J,Zhang F,Gao C,Ma X,Peng X,Kong D,Hao J

更新日期：2017-04-01 00:00:00

abstract：:Most survivors of ischemic stroke remain physically disabled and require prolonged rehabilitation. However, some stroke victims achieve a full neurological recovery suggesting that the human brain can defend itself against ischemic injury, but the protective mechanisms are unknown. This study used selective pharmacolo...

journal_title：Molecular neurobiology

authors： Sun F,Johnson SR,Jin K,Uteshev VV

更新日期：2017-04-01 00:00:00

abstract：:Lactate is an energy substrate in adult brain especially when glucose is withdrawn or only lactate is present as main energy source. Besides, the most abundant lactate transporter in brain-monocarboxylate transporter 1 (MCT1)-was recognized recently. Despite this, MCT1 expressions in central nervous system (CNS) have ...

journal_title：Molecular neurobiology

authors： Zhang M,Ma Z,Qin H,Yao Z

更新日期：2017-04-01 00:00:00

abstract：:Stroke is considered as the second leading cause of death worldwide. The survivors of stroke experience different levels of impairment in brain function resulting in debilitating disabilities. Current therapies for stroke are primarily palliative and may be effective in only a small population of stroke patients. In t...

journal_title：Molecular neurobiology

authors： Hou B,Ma J,Guo X,Ju F,Gao J,Wang D,Liu J,Li X,Zhang S,Ren H

更新日期：2017-03-01 00:00:00

abstract：:Huntington's disease (HD) is a devastating neurodegenerative disease caused by cytosine-adenine-guanine trinucleotide repeat expansion in the huntingtin gene. Growing evidence supports the regulatory functions of long noncoding RNAs (lncRNAs) in the disease process, but little is known about the association between ln...

journal_title：Molecular neurobiology

authors： Sunwoo JS,Lee ST,Im W,Lee M,Byun JI,Jung KH,Park KI,Jung KY,Lee SK,Chu K,Kim M

更新日期：2017-03-01 00:00:00

abstract：:Nicotine, the main component of tobacco smoke, exerts influence on mood, and contributes to physical and psychological dependence. Taking into account frequent concomitance of nicotine abuse and stress, we aimed to research behavioral and biochemical effects associated with nicotine administration in combination with ...

journal_title：Molecular neurobiology

authors： Biala G,Pekala K,Boguszewska-Czubara A,Michalak A,Kruk-Slomka M,Budzynska B

更新日期：2017-03-01 00:00:00

abstract：:Adult neural progenitor cells (NPCs) induce post-ischemic long-term neuroprotection and brain remodeling by releasing of survival- and plasticity-promoting mediators. To evaluate whether secreted factors may mimic neuroprotective and restorative effects of NPCs, we exposed male C57BL6 mice to focal cerebral ischemia a...

journal_title：Molecular neurobiology

authors： Doeppner TR,Traut V,Heidenreich A,Kaltwasser B,Bosche B,Bähr M,Hermann DM

更新日期：2017-03-01 00:00:00

abstract：:The NMDA receptor, which is heavily involved in several human brain diseases, is a heteromeric ligand-gated ion channel that interacts with multiple intracellular proteins through the C-termini of different subunits. GluN2A and GluN2B are the two primary types of GluN2 subunits in the forebrain. During the development...

journal_title：Molecular neurobiology

authors： Sun Y,Cheng X,Zhang L,Hu J,Chen Y,Zhan L,Gao Z

更新日期：2017-03-01 00:00:00

abstract：:Klotho protein, encoded by the Klotho gene (KL) at locus 13q12, is an antiaging hormone-like protein playing a pivotal role in cell metabolism homeostasis and associated to longevity and age-related diseases. In particular, altered cell metabolism in central nervous system may influence the behavior of serotoninergic ...

journal_title：Molecular neurobiology

authors： Paroni G,Seripa D,Fontana A,D'Onofrio G,Gravina C,Urbano M,Addante F,Lozupone M,Copetti M,Pilotto A,Greco A,Panza F

更新日期：2017-03-01 00:00:00

abstract：:Nuclear factor erythroid 2-related factor 2 (Nrf2) is a neuroprotective transcription factor that has recently attracted increased attention. Stroke, a common and serious neurological disease, is currently a leading cause of death in the USA so far. It is therefore of vital importance to explore how Nrf2 behaves in st...

journal_title：Molecular neurobiology

authors： Jiang S,Deng C,Lv J,Fan C,Hu W,Di S,Yan X,Ma Z,Liang Z,Yang Y

更新日期：2017-03-01 00:00:00

abstract：:Experimental autoimmune encephalomyelitis (EAE) is the most used animal model of multiple sclerosis (MS) for the development of new therapies. Dopamine receptors can modulate EAE and MS development, thus highlighting the potential use of dopaminergic agonists in the treatment of MS, which has been poorly explored. Her...

journal_title：Molecular neurobiology

authors： Lieberknecht V,Junqueira SC,Cunha MP,Barbosa TA,de Souza LF,Coelho IS,Santos AR,Rodrigues AL,Dafré AL,Dutra RC

更新日期：2017-03-01 00:00:00

abstract：:In this study, we investigated the influence of elevated RAS expression on the growth of meningioma in vivo and in vitro. The IOMM-LEE cells, representing a cell line derived from malignant meningioma, were divided into blank control group (cells without any drug treatment), negative control group (cells treated with ...

journal_title：Molecular neurobiology

authors： Jiang C,Song T,Li J,Ao F,Gong X,Lu Y,Zhang C,Chen L,Liu Y,He H,Huang O

更新日期：2017-01-01 00:00:00

abstract：:Neural stem cells (NSCs) are hitherto regarded as perspective candidates for cell transplantation in clinical therapies for multilevel spinal cord injury and function restoration. However, the extreme drawbacks of NSCs available for injury transplantation still represent a significant bottleneck in neural regeneration...

journal_title：Molecular neurobiology

authors： Yang H,Liu C,Chen B,An J,Zhang R,Zhang Q,Zhao J,He B,Hao DJ

更新日期：2017-01-01 00:00:00

abstract：:Leukemia inhibitory factor (LIF) has been shown to protect oligodendrocytes from ischemia by upregulating endogenous antioxidants. The goal of this study was to determine whether LIF protects neurons during stroke by upregulating superoxide dismutase 3 (SOD3). Animals were administered phosphate-buffered saline (PBS) ...

journal_title：Molecular neurobiology

authors： Davis SM,Collier LA,Leonardo CC,Seifert HA,Ajmo CT Jr,Pennypacker KR

更新日期：2017-01-01 00:00:00

abstract：:Our previous study has proved that the up-regulation of glial glutamate transporter 1 (GLT-1) played an important role in the acquisition of brain ischemic tolerance after cerebral ischemic preconditioning (CIP) in rats. However, little is known about the mechanism involved in the up-regulation of GLT-1 in the process...

journal_title：Molecular neurobiology

authors： Zhang M,Gong JX,Wang JL,Jiang MY,Li L,Hu YY,Qi J,Zhang LY,Zhao H,Cui X,Xian XH,Li WB

更新日期：2017-01-01 00:00:00

abstract：:Germline and somatic mutations in key genes of the mammalian target of rapamycin (mTOR) pathway have been identified in seizure-associated disorders. mTOR mutations lead to aberrant activation of mTOR signaling, and, although affected neurons are critical for epileptogenesis, the role of mTOR activation in glial cells...

journal_title：Molecular neurobiology

authors： Wang X,Sha L,Sun N,Shen Y,Xu Q

更新日期：2017-01-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most common type of dementia with clinical symptoms that include deficits in memory, judgment, thinking, and behavior. Gangliosides are present on the outer surface of plasma membranes and are especially abundant in the nervous tissues of vertebrates. Ganglioside metabolism, especially ...

journal_title：Molecular neurobiology

authors： Ariga T

更新日期：2017-01-01 00:00:00

abstract：:The human natural killer-1 (HNK-1), 3-sulfonated glucuronic acid, is a glycoepitope marker of cell adhesion that participates in cell-cell and cell-extracellular matrix interactions and in neurite growth. Very little is known about the regulation of the HNK-1 glycan in neurodegenerative disease, particularly in Alzhei...

journal_title：Molecular neurobiology

authors： García-Ayllón MS,Botella-López A,Cuchillo-Ibañez I,Rábano A,Andreasen N,Blennow K,Ávila J,Sáez-Valero J

更新日期：2017-01-01 00:00:00

abstract：:Accumulating evidences indicate that endogenous modulators of excitatory synapses in the mammalian brain are potential targets for treating neuropsychiatric disorders. Indeed, glutamatergic and adenosinergic neurotransmissions were recently highlighted as potential targets for developing innovative anxiolytic drugs. A...

journal_title：Molecular neurobiology

authors： Almeida RF,Comasseto DD,Ramos DB,Hansel G,Zimmer ER,Loureiro SO,Ganzella M,Souza DO

更新日期：2017-01-01 00:00:00

abstract：:The complement component (3b/4b) receptor 1 gene (CR1) is considered as one of the most important genetic susceptibility loci in Alzheimer's disease (AD). However, to date, few studies were performed to discover the possible effect of CR1 genetic variants on AD pathology in the brain. Here, we evaluated the potential ...

journal_title：Molecular neurobiology

authors： Zhu XC,Wang HF,Jiang T,Lu H,Tan MS,Tan CC,Tan L,Tan L,Yu JT,Alzheimer’s Disease Neuroimaging Initiative.

更新日期：2017-01-01 00:00:00

abstract：:Mild cognitive impairment (MCI) is considered as an intermediate zone between normal aging and dementia. The most prominent feature of MCI is an isolated mild decline in memory, whereas other cognitive functions remain intact. The symptoms of vascular cognitive impairment (VCI) range from MCI to dementia, and an anima...

journal_title：Molecular neurobiology

authors： Yang EJ,Cai M,Lee JH

更新日期：2016-12-01 00:00:00

abstract：:Manganese (Mn) is widely regarded as a neurotoxic heavy metal that causes learning and memory deficits. Recently, it has been proved that the striatum is related to memory and learning ability. However, no previous study focused on the effect of Mn-induced learning and memory deficits on the striatum. This study aims ...

journal_title：Molecular neurobiology

authors： Song Q,Deng Y,Yang X,Bai Y,Xu B,Liu W,Zheng W,Wang C,Zhang M,Xu Z

更新日期：2016-12-01 00:00:00

abstract：:α-Synuclein (α-syn) has been recognized to induce neuroinflammation and to disturb nerve repair process in Parkinson's disease. However, the potential mechanisms underlying α-syn-induced impairment of adult neurogenesis remain unclear. In the present study, A53T mutant α--synuclein transgenic (A53Ttg/tg) mice, caspase...

journal_title：Molecular neurobiology

authors： Fan Z,Lu M,Qiao C,Zhou Y,Ding JH,Hu G

更新日期：2016-12-01 00:00:00

abstract：:Thyroid hormone plays an important role in central nervous system (CNS) development, including the myelination of variable axonal calibers. It is well-established that thyroid hormone is required for the terminal differentiation of oligodendrocyte precursor cells (OPCs) into myelinating oligodendrocytes by inducing ra...

journal_title：Molecular neurobiology

authors： Lee JY,Petratos S

更新日期：2016-11-01 00:00:00

abstract：:Studies have shown that neurofibromin (NF1) restricts GABA release at inhibitory synapses and regulates dendritic spine formation, which may play an important role in temporal lobe epilepsy (TLE). NF1 expression was detected by double-label immunofluorescence, immunohistochemistry, and western blot analysis in the bra...

journal_title：Molecular neurobiology

authors： Ren M,Li K,Wang D,Guo J,Li J,Yang G,Long X,Shen W,Hu R,Wang X,Zeng K

更新日期：2016-11-01 00:00:00

abstract：:Phospholipase C beta 1 (PLCβ1) expresses in gliomas and cultured glial cells, but its expression is barely detectable in normal glial cells. We analyzed data from Gene Expression Omnibus (GEO-GDSxxx), The Cancer Genome Atlas (TCGA), and the Repository for Molecular Brain Neoplasia Data (REMBRANDT) to explore the poten...

journal_title：Molecular neurobiology

authors： Lu G,Chang JT,Liu Z,Chen Y,Li M,Zhu JJ

更新日期：2016-11-01 00:00:00

abstract：:Oxidative damage to the inner ear is responsible for several types of sensorineural deafness. Cochlear stria marginal cells (MCs) are thought to be vulnerable to such oxidative stress. Activated poly(ADP-ribose) polymerase 1 (PARP1) has been implicated in several diseases, but the effect of PARP1 on MCs subjected to o...

journal_title：Molecular neurobiology

authors： Zhang Y,Yang Y,Xie Z,Zuo W,Jiang H,Zhao X,Sun Y,Kong W

更新日期：2016-11-01 00:00:00

abstract：:Neuronal differentiation plays a key role during embryogenesis. However, based on the capacity of neuronal stem cells to either generate or regenerate neurons and because differentiation stops aberrant neuroblasts proliferation, neuronal differentiation is crucial during neuropathological conditions. Although phosphat...

journal_title：Molecular neurobiology

authors： Paoletti L,Domizi P,Marcucci H,Montaner A,Krapf D,Salvador G,Banchio C

更新日期：2016-11-01 00:00:00

abstract：:In the present study, we identified the effects of inhaled Pimpinella peregrina essential oil (1 and 3 %, for 21 continuous days) on scopolamine-induced memory impairment, anxiety, and depression in laboratory rats. Y-maze and radial arm-maze tests were used for assessing memory processes. Also, the anxiety and depres...

journal_title：Molecular neurobiology

authors： Aydin E,Hritcu L,Dogan G,Hayta S,Bagci E

更新日期：2016-11-01 00:00:00

abstract：:c-Jun N-terminal kinases (JNKs), which belong to a mitogen-activated protein kinase (MAPK) family, are involved in the regulation of several physiological functions in mammals and act as mediators of apoptosis, obesity, and memory storage in the brain, including the processes of neuronal de- and regeneration. JNK subf...

journal_title：Molecular neurobiology

authors： Petrov D,Luque M,Pedrós I,Ettcheto M,Abad S,Pallàs M,Verdaguer E,Auladell C,Folch J,Camins A

更新日期：2016-11-01 00:00:00

abstract：:Stroke is the leading cause of severe disability, and lacunar stroke is related to cognitive decline and hemiparesis. There is no effective treatment for the majority of patients with stroke. Thus, stem cell-based regenerative medicine has drawn a growing body of attention due to the capabilities for trophic factor ex...

journal_title：Molecular neurobiology

authors： Jablonska A,Drela K,Wojcik-Stanaszek L,Janowski M,Zalewska T,Lukomska B

更新日期：2016-11-01 00:00:00

abstract：:A recent genome-wide association study conducted in Caucasians has identified glutaminyl-peptide cyclotransferase (QPCT) gene as a susceptibility gene for schizophrenia, as its common single nucleotide polymorphism (SNP) rs2373000 was significantly associated with the risk of this disease. To date, this finding has no...

journal_title：Molecular neurobiology

authors： Zhang QQ,Jiang T,Gu LZ,Zhu XC,Zhao HD,Gao Q,Zhu HQ,Zhou JS,Zhang YD

更新日期：2016-11-01 00:00:00

abstract：:GLI2 is a key mediator of the sonic hedgehog (Shh) signaling pathway and plays an important role in neural tube development during vertebrate embryogenesis; however, the role of gli2 in human folate-related neural tube defects remains unclear. In this study, we compared methylation status and polymorphisms of gli2 bet...

journal_title：Molecular neurobiology

authors： Lu XL,Wang L,Chang SY,Shangguan SF,Wang Z,Wu LH,Zou JZ,Xiao P,Li R,Bao YH,Qiu ZY,Zhang T

更新日期：2016-10-01 00:00:00